Title Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population

In this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from Genome Wide Association studies (GWAS) in southern Chinese population. 812 participants consisting of 462 late-onset Alzheimer's disease (LOAD) patients and 350 non-demented controls were recruited. We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p=0.035, adjusted genotypic p=0.043) and CLU (rs2279590 adjusted allelic p=0.035, adjusted genotypic p=0.006; rs11136000 adjusted allelic p=0.038, adjusted genotypic p=0.009) were significantly different between LOAD patients and non-demented controls. For PICALM, LOAD association was found only in the APOE ε4 (subgroup up (rs3851179 adjusted allelic p=0.028, adjusted genotypic p=0.013). Our findings showed evidence of CR1, CLU and PICALM and LOAD susceptibility in an independent southern Chinese population, which provides additional evidence for LOAD association apart from prior GWAS in Caucasian population.